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Derma Pearl - 60ml
Advanced Resveratrol Anti-Aging Skin Creme
Derma Pearl is the first anti-aging cosmeceutical that operates at the DNA level to permanently reverse the signs of aging and protect against future damage. We guarantee that in one month or less of daily use you will experience a profound improvement in skin quality that no other natural or prescription product can replicate.
 Derma Pearl has evolved. The new name of our hugely successful age reversal cream is Celle. Celle is the world's first skin cream to combine Live Active Plant stem cells with resveratrol, hexapeptides, potent antioxidants and natural UV protection. All orders made from 20 November will be filled with the new Celle age reversal cream at no additional cost.
BIOTIVIA has again set the standard for all others to strive for. Celle will be made in our state of the art facility in Bergamo Italy from natural ingredients and packaged in an elegant new frosted glass jar of Italian design.
You have nothing to lose but your wrinkles.
 The primary cause of skin aging and damage is the accumulation of DNA errors due to radiation from the sun, oxidative stress from energy production at the mitochrondria level, environmental toxins, less than perfect diet and the stresses we all experience from our modern lifestyle. Only by enhancing the body's natural DNA repair mechanisms can this damage be reversed and new damage prevented. Resveratol is one of very few compounds that have been shown to up molulate DNA repair in mamallian cells.
This genetic approach represents a revolution in anti-aging skin care treatments. Until now all so-called anti-aging creams and serums have only attemped to fight the outward signs of aging. None have attacked the actual biochemical causes. Not only does Derma Pearl fight aging it actually reverses much of the accumulated damage to the skin. This damage shows up in the form of wrinkles, lines, creases and a general lack of lustre, skin tone and elasticity. No simple moisturizer can reverse this damage.
Resveratrol and the other potent antioxidants in Derma Pearl have been shown in numerous scientific studies by prestigous organizations such as Harvard University, and many other medical schools and researchers to increase the rest phase of cell division. This is the phase during which DNA repair takes place. Resveratrol also activates other metabolic and biological pathways and processes which induce DNA repair and destroy damaged or abberant cells. The antioxidants in Bio Shape quench the free radicals that cause oxidative stress damage to the skin.
If you compare Derma Pearl with virtually all other skin care treatments the first thing you will notice is that Derma Pearl cream is a light tan color unlike the other products, that are bright white. There is a simple reason for this. Derma Pearl contains a high concentration of active ingredients. It is these ingredients which give Derma Pearl a rich soft skin color. Most active botanical compounds are not naturally white in color. Our priority was to make the most effective product not the one that conforms to the traditional norms for cosmetics. The color of Derma Pearl is actually assurance that it contains substantial amounts of the active ingredients such as resveratrol, pearl extract, idebenone, acetyl hexapeptide 8 (so-called Botox in a jar), and other hexapeptides.
Other anti aging creams that boast of resveratrol's benefits contain so little of this compound as to be ineffectual. Purified trans-resveratrol is a costly raw material and to be effective a cream must have a high concentration of the most potent resveratrol isomer. Biotivia is the world's leading resveratrol producer. We pioneered the first and still most effective and highly aclaimed resveratrol products. Quality, experience, and scientific resources count when it comes to the manufacture of any resveratrol-based product.
Derma Pearl by Biotivia is a truly unique and advanced cosmeceutical, the result of years of investigation and the scientific expertise of Biotivia, the company who produced the first evidence-based anti-aging product line based upon peer reviewed studies, and whose resveratrol formulation is the clear choice of medical research organisations including Harvard Medical school, Albert Einstein Medical College, the National Institutes of Health and many other prestigious institutions currently doing human trials of the disease prevention and anti-aging properties of resveratrol.
 Derma Pearl is far more than simply a cosmetic application or traditional skin care product. The bio-enhanced resveratrol, hexapeptide 3, water soluble antioxidants and other active ingredients in Derma Pearl skin cream actually penetrate the skin where it works at the DNA and metabolic levels to stimulate the production of new muscle, skin and collagen. Biotivia's proprietary high-potency resveratrol, the so-called miracle molecule extract of red wine, was shown by researchers at Harvard and other institutions to switch on the cells anti aging genes called sirtuins. Dr. Sinclair's work on this compound has been replicated by other researchers and has been published in the renowned journals Nature and Cell.
The effect of the improvement in skin health and vitality is that the skin becomes younger, firmer, more elastic, and blemishes, color spots and uneven complexion are eliminated.
Derma Pearl's effects are visible in just two weeks. In six weeks you will see a remarkable transformation in skin quality, brilliance and smoothness to the touch. You will see lines and crows feet disappear or diminish within weeks. Deeper creases in the skin and dark spots will begin to diminish within 60 to 90 days, and the beneficial effects will not quickly wear off should you stop using Derma Pearl.
The advanced antioxidants, peptides, amino acids, skin repair compounds, and UV blockers in Derma Pearl create a unique and extremely effective formulation that goes well beyond any other skin care treatment in its ability to restore, reinvigorate and repair your skin and to stimulate your own cells to produce new youthful collagen and elastin.
Comparing conventional skin care products to Derma Pearl is analogous to comparing a good mineral water to vintage Champagne. There has never been a skin care product which is able to actually restore skin quality and repair sun damage through the genetic, metabolic and biochemical mechanisms through which Derma Pearl operates. This is why we are able to guarantee its effectiveness.
Derma Pearl´s two principal proven age reversal ingredients are bio-enhanced resveratrol and Acetyl Hexapeptide 8. This astonishing compound works at the DNA and metabolic levels to greatly improve skin quality and reverse collagen cross linking and wrinkles as well as the other effects of sun exposure and aging. Resveratrol uniquely activates the Sirt-1,2 anti-ageing genes, increases the mitochondria density and vitality, reduces inflammation and redness, and stimulates new collagen production. Resveratrol has also been shown in numerous peer-reviewed scientific studies to protect skin against the most serious effects of long term UV exposure and to actually reverse the existing damage. The second remarkable ingredient is Acetyl Hexapeptide 8, discovered by a scientist in Spain, this compound mimics the effects of Botox*, without the needles, toxicity or side effects. Instead of killing the nerve, Acetyl Hexapeptide safely interrupts the signal from the nerve to the muscle without damaging either. You will see discernable effects of this compound within four to six weeks of regular use of Derma Pearl.
In addition to resveratrol, concentrated pearl extract, and acetyl hexapeptide 8, Derma Pearl contains advanced natural antioxidants, collagen growth stimulators, skin damage repair agents, UV blockers, and gentle plant-based anti-inflammatory compounds. Derma Pearl is the only treatment you will need to restore your skin quality and keep the age effects at bay. Suitable for all skin types, Derma Pearl is most effective on wrinkled, sun damaged and dry and devitalised skin. It will improve skin tone, texture and radiance, and will rejuvenate and regenerate your skin as well as reverse sun damage, and protect the skin from exposure to the common environmental toxins and oxidative stress caused by free radicals.
Derma Pearl is oil-free and won´t leave a greasy feeling on your skin. We believe that it is superior to all existing creams and serums as an age-reversal and anti-wrinkle restorative treatment. Derma Pearl is ideal for women and men who seek to reverse the effects of sun and aging on the skin of the face, neck, hands and arms.
Use day and night on clean skin. Massage lightly on face, neck and eye contour. Do not appy near the eyelash line or on lower eyelid. Combine it with Biotivia´s Transmax anti-aging supplement for a total, inside and out anti-ageing treatment. Derma Pearl is scented with a subtle but stimulating natural citrus and vanilla oil fragrance.
Derma Pearl resveratrol skin cream is designed to be used on the face, arms and hands. In less than six weeks you will notice a definite improvement in skin tone, complexion, color and texture.
 No other natural or synthetic treatment produces the extent of improvement you will experience with Derma Pearl resveratrol skin cream.
Compared to premium anti-aging skin creams by the well known names in cosmetics, which do not contain resveratrol or the other essential active botanical compounds found in this product, Derma Pearl is an extremely good value. Our price is a function of the advanced active ingredients and technologies which are found in Derma Pearl, not elaborate marketing campaigns and costly packaging. We believe that you will find it a well worth the cost. Derma Pearl is the best product science can offer to reverse skin aging and protect against the future effects of aging. We guarantee it.
Tangible Age Reversal Effects You Will Experience
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Clearly Discernable reduction in deeper wrinkles and creases.
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Profoundly revitalized skin health and appearance and reversal of the damage caused by years of exposure to the sun and environmental toxins.
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Improved skin texture and a more even and lighter overall skin color resulting in a younger appearance and greatly improved feel to the touch.
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Protection from the future signs of aging.
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Disappearance or dramatic reduction of unsightly "crow's feet"
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Re-energized, firmer and smoother skin.
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Brightening of the skin tone and a more radiant appearance to your skin.
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Diminished appearance and lightening of age-spots.
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Reduced dark circles and puffiness around the eyes.
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Daily protection against damaging UVA and UVB rays Protection from the effects of the sun and environmental pollutants by the advanced antioxidants and UV blockers in Derma Pearl.
Within six weeks of twice daily application of Derma Pearl our test subjects experienced:
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Serious reduction in the depth of of lines and wrinkles
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Improved skin tone and overall skin color resulting in a younger appearance and greatly improved texture
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Protection from the future signs of aging
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Profoundly revitalized skin health and youthful appearance
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Improved skin firmness and elasticity
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Disappearance or dramatic reduction of unsightly "crow's feet"
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Re-energized, firmer and smoother skin
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Improved skin tone, and brightening
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Diminished redness and lightening of age-spots
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Reduced dark circles and puffiness around the eyes
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Daily protection against damaging UVA and UVB rays
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Protection from the drying and weathering effects of the environment by the advanced antioxidants in Derma Pearl
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Discernable age reversal effects of resveratrol, Ferulic acid, Pearl extract, and Idebenone on skin quality and appearance
Botox is the registered Trademark of the Allergin corporation.
Our Guarantee: If you do not experience a discernable improvement in skin quality in one month of daily use we will refund your purchase price.
Why Choose Derma Pearl Age-Reversal Skin Treatment?
By basing Derma Pearl on state of the art anti-aging science, rather than hype and marketing, we have formulated the most advanced, most potent and most effective anti-aging skin treatment available anywhere at any price. It is that simple. No other product compares with Derma Pearl in the one feature that we believe is most important; the effectiveness and potency of the actual ingredients. Derma Pearl anti-aging skin cream was created by a team of biochemists, pharmacists, botanists and dermatologists to be the most effective anti-aging skin care product possible, not simply the most effective over the counter skin treatment but the most effective one of all those available with or without a prescription. The formulation is based upon solid peer-reviewed scientific evidence, human trials and laboratory studies. Derma Pearl skin cream is far more than a moisturizer or temporary remedy for fine lines and blemishes. Derma Pearl works at the genetic, metabolic and systemic levels to repair damaged skin and dramatically improve skin texture, color and brightness and to remove blemishes, lines and imperfections. Derma Pearl is a potent cosmeceutical, not simply a fancy cosmetic.
Biotivia has set a new standard for all future anti-aging products to strive for. We have invested three years of intense study, testing and refinement to create the world's most efficacious formulation of scientifically proven compounds in a high-potency serum that is unlike anything you have ever used before. Most cosmetics are manufactured by companies well known for their brilliant marketting and gorgeous packinging. Biotivia's strengths are in its staff of scientists, dermatologists and botanical specialists. This means that our focus is on results for you, not in designing a dramatic ad campaign to run on national TV and the fashion magazines. This also means that with Derma Pearl anti-aging skin cream you get unique, potent and advanced costly ingredients, not simply a boost to your ego. If your priority is better complexion, healthier skin and protection against aging Derma Pearl is clearly your best choice in anti-aging skin care products. We guarantee it.
Active Ingredients in Derma Pearl Age Reversal Skin Cream
It is our ingredients, not our packaging, adverts or hype that makes Derma Pearl skin cream the best age-reversal product available anywhere, with or without a prescription.
The Ingredients in Derma Pearl resveratrol anti-aging skin cream were selected based upon their scientifically proven ability to permanently improve skin health and appearance.
Trans-resveratrol
This is the most active isomer contained in resveratrol, the so-called miracle red wine molecule. Resveratrol has been shown to retard aging in mammals, reduce inflammation, promote improved DNA repair, and switch on the SirT-1,2 anti-aging genes in human cells. In a study done at Province College, Biology Department in 2008 it was found that SIRT1 is involved in UV-induced AMP-activated protein kinase (AMPK) and downstream Acetyl-CoA Carboxylase (ACC), phosphofructose kinase-2 (PFK-2) phosphorylation. This data provide new insights into understanding of the molecular mechanisms of UV-induced skin aging, suggesting that SIRT1 activators such as resveratrol could serve as new anti-skin aging agents. Biotivia is the acknowledged leader in resveratrol manufacturing and the creation of advanced formulations based upon resveratrol and complementary polyphenols, antioxidants and natural anti-aging compounds.
Collagen Synthesis Compounds
Collagen makes up about 70% of our skin's dry weight. As any material, it is subject to wear and tear, and slowly breaks down over time. In our youth, fibroblasts (skin cells – capable of producing collagen) replace broken collagen fibers. But as we age our skin's ability to replace damaged collagen diminishes. This leads to wrinkles and sagging skin and more vunerable to damage by UV rays. We could apply collagen creams but remember, collagen being a big molecule does not penetrate our skin and may expose us to the dangers of mad cow disease. We could get collagen injections, but one of the main drawbacks besides costs is injected collagen is quickly broken up by enzymes. Derma Pearl actually stimulates the production of your own natural collagen. The active botanicals in Derma Pearl which function to enhance collagen are resveratrol, ferulic acid, idebedone, palmitoyl oligopeptide, and palmitoyl tetrapeptide.
Ferulic acid
Ferulic acid will reduce fine lines, wrinkles, age spots and sagging skin. It also helps to increase the elasticity and resilience of the skin, repairs UV-induced skin damage and skin aging, stimulates collagen and elastin production, suppresses UV radiation-induced oxidative reactions, acts synergistically with Vitamin C and E to improve their potency and has shown excellent anti-inflammatory properties in numerous scientific studies. Ferulic is safe and easily absorbed by the skin. Its ability to repair sun damaged skin makes it an important component of Derma Pearl.
Pearl extract
Pearl extract contains protein complexes, amino acids and polysaccharides which counteract the visible effects of chronological skin ageing. Provides essential skin nourishment, Renews skin cells, often damaged by our hectic life styles, stress, overwork, environmental pollutants, and lack of exercise. Stimulates skin cells’ metabolism replenishes deep skin moisture level evens and whitens skin color and improves skin glow and skin tone.
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Pearl is a valuable mineral source, contributing calcium, magnesium, zinc, strontium, selenium and copper, which aid in supplementing skin and bone vitality.
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Contains dozens of amino acids that are necessary for maintaining health, including eight that cannot be produced by the body.
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Participates in the development in RNA and DNA.
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Promotes the activities of important natural antioxidant enzyme SOD, aiding in the prevention of development of melanin (which can cause freckles, dark patches and blemishes on the skin, including pimples and boils).
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Aids in the regeneration of skin cells, contributing to healthy, smooth skin.
Idebenone
Idebenone is well defined as a crucial component of the oxidative phosphorylation process in mitochondria which converts the energy in carbohydrates and fatty acids into ATP to drive cellular machinery and synthesis. Evidence for a function in redox control of cell signaling and gene expression is developing from studies on idebenone stimulation of skin cell growth.
European scientists conducted double-blind placebo tests on the efficacy of idebenone on aging-skin and wrinkles. They concluded idebenone drastically reduces free-radical damage to skin. Furthermore, It showed great capacity to reduce the most stubborn form of wrinkles - crow's feet. Antioxidants protect cells from environmental damage, improve the appearance of fine lines, reduce dryness, and smooth skin texture. Idebenone has far greater skin penetration potential and a much higher oxidative stress protection capacity than virtually any other antioxidant. Its lower molecular weight allows for greater skin penetration and extended shelf life stability. After six weeks' use of a 1.0% idebenone formula, a 26% reduction in skin roughness/dryness was observed, a 37% increase in skin hydration, a 29% reduction in fine lines/wrinkles, and a 33% improvement in overall global assessment of photodamaged skin.
Acetyl Hexapeptide-8, The Safe Botox* Alternative
Scientists in Spain have discovered a compound called Acetyl Hexapeptide-3, which evidence suggests, offers the same results as Botox without needles or the risk of damage to the skin or facial muscles. In other words, many doctors believe Acetyl Hexapeptide-3 has a similar mechanism of action as Botox... without the toxicity, pain and expense. Dr. Sumayah Jamal, MD (Assistant Professor of Dermatology at the NYU School of Medicine in New York City) says on Acetyl
Hexapeptide-8
"Botox* works by destroying a protein involved in the release of a neurotransmitter that would otherwise keep a muscle tense, allowing a wrinkle to form," By stopping the tensing motion and relaxing the muscle, the wrinkle seems to disappear, she says.The Acetyl Hexapeptide-3 operates to mimic that same Botox action by blocking the action of the protein. It doesn't destroy the protein, like Botox does, says Jamal, but instead simply keeps it from connecting to the cell and turning on the muscle contraction. The end result, she says, may be similar to medical procedures. Acetyl Hexapeptide-3 blocks the nerve signals (neurotransmitters) that control the contraction of facial muscles. This produces a significant reduction in the appearance of both the depth and size of fine lines and wrinkles. Unlike Botox, Acetyl Hexapeptide-3 does not involve paralysis, toxins or side effects.
In a clinical study published in the International Journal of Cosmetic Science, acetyl hexapeptide-3 at a 10% concentration has been shown to reduce the depth of wrinkles up to 30% after 30 days of use.
Palmitoyl oligopeptide
Palmitoyl Oligopeptide is a tripeptide. It enhances the product of collagen and GAGs and stimulates the growth of matrix and connective tissues enabling to become moisturized, soft and defined.
To test the wrinkle fighting properties of Palmitoyl oligopeptide-3, a study was performed on 24 female volunteers aged 42 to 66 years old. The volunteers applied a liquid foundation containing 2% Palmitoyl oligopeptide-3 once daily for two months. Images of the skin were examined microscopically. The size of wrinkles was found to decrease up to 36% with a 14% average decrease. The depth of wrinkles was found to decrease up to 27% with a 10% average decrease. For some subjects, deep wrinkles were nearly eliminated. On average, deep wrinkles decreased 40%. Medium wrinkles decreased up to 86%, with an average decrease of 25%.
Palmitoyl Tetrapeptide 3 (PT-3)
PT-3 is a synthetic peptide comprised of four amino acids whose sequence is SSNA (Serine,Serine, Asparagine, Alanine). As in PP-3, palmitic acid is attached to the peptide chain as a penetration enhancer to drive the peptide through the stratum corneum. PT-3 was formulated with the goal of suppressing the body’s production of excess interleukins, the chemical messengers which trigger the body’s acute inflammatory response which leads to glycation damage. Glycation affects the skin's support system—collagen, elastin and other proteins—and leads to wrinkles, sagging, loss of youthful contours and uneven skin tone. Inflammation is normally a protective response to tissue injury or destruction and is an important part of the body’s immune response.
As we age,the hormonal regulatory system begins to break down and significant levels of interleukins are found in the plasma even when there is no inflammatory stimulus. This results in high levels of inflammatory proteins in the tissues, slow tissue regeneration, tissue rigidity and a loss of healing potential. Theoretically, if the production of excess interleukins can be suppressed, the inappropriate inflammatory response will not be triggered and glycation damage will be inhibited.
PT-3 induced a marked dose-dependent reduction in interleukin production. The higher the concentration of Palmitoyl Tetrapeptide 3, the greater the reduction in interleukin production – up to 40%. UV radiation is known to accelerate interleukin production. When the scientists exposed cells to UV radiation and then added PT-3, they achieved an 86% reduction of interleukin production.
In a recent double blind study, 15 volunteers applied a gel containing 3% Palmitoyl tetrapeptide-3 to the forearm twice a day for 14 days. The smoothness of the skin was then measured microscopically. Palmitoyl tetrapeptide-3 increased skin regularity by 23% and decreased skin roughnessby 14%.In a second blind study, 16 volunteers applied a gel containing 3% Palmitoyl tetrapeptide-3 to the forearm twice a day for 14 days. The hydration level of the skin was then measured. Palmitoyl tetrapeptide-3 increased skin hydration by
Vitamin C
Vitamin C helps plump up thinning skin by increasing its production of new collagen. With Vitamin C stimulating collagen production there is no known risk of allergy, no immune reaction and no injection-induced infection. Just natural collagen being deposited in an orderly fashion rapidly bringing back skin's softness, strength and elasticity. Vitamin C is an antioxidant essential to human health which has been shown to strengthen capillaries, which means fewer broken small veins are visible on your face.
Vitamin C also helps regulate the production of dark color producing cells. It helps correct and restore the balance of lackluster skin, dark patches and blotchiness. This evens skin tone and results in a dramatic improvement in skin radiance.
Vitamin C helps reduce evaporative water loss from skin, thus retaining moisture within the skin. Vitamin C in the form of Ascorbyl Palmitate is used in our cream preparation. This form is more easily absorbed into the skin.
Vitamin E
Vitamin E is possesses free radical scavenging, moisturizing, anti-inflammatory, and antioxidant properties which help protect the cellular membrane from free radical damage, improves the skin's water binding abilities (retains moisture) and has xcellent anti-inflammatory properties (reduces wrinkles). Moreover this essential nutrient moisturizes the skin and enhances skin smoothness.
Sunscreen ingredients
Avobenzone and octyl salicylate are the two most effective sun screen compounds approved by the FDA for use in skin creams.
*Botox is a registered trademark by the Allergan corporation. Derma Pearl does not contain this neuro toxin.
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